Large-scale in silico mapping of complex quantitative traits in inbred mice. Issue 4 Issue 3 Issue 2 Issue 1. Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Retired breeder rabbits have been used for models of cell-based treatment for acute myocardial infarction and seem to be a reasonable model for human disease [ - ]. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. At puberty, however, T and other androgens cause virilization, including growth of the phallus and scrotum, deepening of the voice and development of male-typical musculature.
Organization for the Study of Sex Differences (OSSD) Third Annual Meeting
Paper presented at the. Effect of hypercholesterolemia on vascular reactivity in the rabbit. Expression quantitative trait loci: Tissue-specific expression and regulation of sexually dimorphic genes in mice. The gold standard for measurement of sex steroids such as testosterone is liquid chromatography linked with mass spectroscopy [ ].
Organization for the Study of Sex Differences Annual Meeting - Robert Meisel
They were first discovered in area of the Dominican Republic The presence of sperm on the vaginal smear or presence of a sperm plug is termed 'day 1 of pregnancy'. AFPep, a novel drug for the prevention and treatment of breast cancer, does not disrupt the estrous cycle or fertility in rats. Accounting for sex in the design and interpretation of studies including pharmacological effects of drugs is essential to increase the foundation of basic knowledge upon which to build translational approaches to prevent, diagnose and treat cardiovascular diseases in humans. Can sex differences in science be tied to the long reach of prenatal hormones? In , the Institute of Medicine advocated that a better understanding of differences in human diseases between males and females, with translation of these differences into clinical practice, requires consideration of sex as an important biological variable in design of basic research [ 5 ]. Analysing complex genetic traits with chromosome substitution strains.
The assessment of strain and sex differences between different mouse strains is greatly facilitated through searchable online strain phenotypic characteristic databases and simple push-button statistical analysis tools, such as those provided in the Mouse Phenome Database [ ] http: Prices are for evaluation only. Sexually dimorphic gene expression in the heart of mice and men. This analysis is separate from incorporating sex in multivariate analysis of data. A full description of these molecular mechanisms is beyond the scope of this article. Whether or not this also the case for sex-biased gene expression on the brain remains unknown and is likely to vary by brain region.